Analysis Note

ControlHuman Lymphocytes

Application

Research Sub CategoryImmunoglobulins & Immunology

Research CategoryInflammation & Immunology

This Milli-Mark Anti-CD68-FITC Antibody, clone KP1 is validated for use in FC for the detection of CD68.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

CD68 is highly glycosylated lysosomal membrane protein with an Mr of 110,000. The CD68 protein belongs to a family of lysosomal glycoprotein (LGP)/plasma membrane shuttling proteins that play a role in endocytosis and/or lysosomal trafficking. CD68 is expressed strongly in cytoplasmic granules, and weakly on the surface of macrophages, monocytes, neutrophils, basophils, and NK cells. CD68 can also be found in the cytoplasm of non-hematopoietic tissues, especially the liver, and renal glomeruli, and tubules (Goyert, 1997).

Immunogen

Lysosomal fraction of human lung macrophages

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Quality

Evaluated by flow cytometry using human lymphocytes

Specificity

Antibody recognizes Human CD68 antigen.

Storage and Stability

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Target description

110 kDa (Goyert, 1997)